András Spät, MD, PhD

Professor Emeritus

Member of the Hungarian Academy of Sciences

Member of Academia Europaea

Department of Physiology

Faculty of Medicine

Semmelweis University

Location: Budapest IX., Tűzoltó u. 37-47.

Mailing address: H-1428 Budapest, PO Box 2, Hungary

e-mail: Spat@eok.sote.hu , Spat@t-online.hu

Curriculum Vitae of Dr. András Spät

Born: Budapest, Hungary, 7 November 1940

University studies:
1958-1964: Budapest (presently Semmelweis) University Medical School, Budapest

Degrees:

1964: Doctor of Medicine
1975: Candidate of Sciences (corresponds to Ph.D.)
1982: Doctor of Sciences (in Medicine)
1993: Corresponding member of the Hungarian Academy of Sciences
1998: Full member of the Hungarian Academy of Sciences
1999: Member of the Academia Europaea

Jobs, positions:

in the Dept. of Physiology, Semmelweis University, Budapest:

1960-1962: research student
1962-1964: instructor
since 1964: staff member (assistant professor, lecturer, senior lecturer)
1986-2010: Professor of Physiology
1995-2005: Head of Department
2010-: Professor Emeritus

Teaching activity in the Semmelweis University:

1962-1995: laboratory courses in Physiology
1967-2017: lectures on Physiology
1982-1995: supervisor of the laboratory courses in Physiology
1990-2000: Chairman of the Union of Research Students
1993-2007: head of the ‘Cellular and Molecular Physiology’ PhD Program

Scientific publications (as on 30 May 2018)

4 university textbooks (coauthor)
2 monographies (in Hungarian)
5 monography chapters (in English)
120 publications in recognized scientific journals (in English)

Cumulative impact factor: before 1975: » 26.5, since 1975: 430

Citations: > 5500

Hirsch index: 37

Prizes and awards:

1967: Decoration for University Studies (donated by the Minister of Education)
1973: Géza Farkas Prize of the Hungarian Physiological Society
1980: research prize donated by the President of the Hungarian Academy of Sciences
1982: Decoration for Life Saving (donated by the Hungarian Government)
1987: „Academy Prize” of the Hungarian Academy of Sciences
1992: Albert Szent-Györgyi Prize (donated by the Minister of Education)
1992: European Medal of the Society for Endocrinology (U.K.)
1995: Arnold Ipolyi Award (National Science Foundation)
1996: Semmelweis Memorial Award (Semmelweis University, Budapest)
1997: Honoris Causa Pro Scientia Gold Medal (National Council of Scientific Research Students)
1998: Péter Pázmány Award for University Teaching (Pro Renovanda Cultura Hungariae)
2002: Leo Szilárd Award (ALCOA Foundation and Hungarian Higher Education and Research Foundation)
2002: Batthyány-Strattman Prize (Minister of Health)
2004: Széchenyi Prize (President of the Republic)
2007: Fogarty Scholar

Positions abroad:

1968-1969: Institute for Experimental Hormone Research, University of Copenhagen, Copenhagen, Denmark (Prof. Ejgil Bojesen, 6 months)
1984-1985: ECFMG Fellow: Dept. of Pharmacology, Medical College of Virginia, Richmond, VA (Prof. R.P. Rubin, 1 year)
1989-1990: Professeur Invité Louis Jeantet, Institute of Clinical Biochemistry, University of Geneva, Geneva, Switzerland (Prof. C.B. Wollheim, 1 year)

Professors who were members of Spät’s team

Balla Tamás (NIH, Bethesda MD)
Czirják Gábor
Enyedi Péter
Fazekas Árpád
Hajnóczky György (Philadelphia, PA)
Hunyady László
Ludwig Endre
Rohàcs Tibor (New Jersey)
Sarkadi Balázs
Szabó Béla (Freiburg)
Szabadkai György (London)
Vàrnai Péter

Members of the Hungarian Academy of Sciences who were members of Spät’s team

Balázs Sarkadi
László Hunyady
Tamás Balla
György Hajnóczky

Scientific committees and editorial boards:

1969-1993: Editorial Board of the Journal of Steroid Biochemistry and Molecular Biology
1991-1996: chairman of the Section of Physiological Sciences of the (Hungarian) National Science Foundation
1991-2004: chairman of the Endocrinological Committee of the (Hungarian) Council for Medical Research
1993-1997: Executive Committee of the Association of the European Journal of Endocrinology
1996-1998: Board of the University Research and Development Grants
1997-2010: chairman of the Habilitation Committee of the Semmelweis University
1997-2006: vice-president of the National PhD and Habilitation Committee
1997 – : Editorial Board of Magyar Tudomány
1998 – : Editorial Board of Acta Physiologica Acad. Sci. hung.
2004-2009 : Editorial Board of Physiological Reviews
2005 – : Editorial Board of Cell Calcium

Specific scientific interest: molecular endocrinology, signal transduction

Scientific activity:

1962-1963: demonstration of the effect of aldosterone on intestinal sodium and potassium transport
1964-1969: studies on the role of the kidney in the control of aldosterone secretion in the rat
1970-1974: demonstration of the aldosterone secretory effect of prostaglandins
1971-1973: development of a protein binding assay for corticosterone, first application of aldosterone RIA in rat experiments
1974-1981: studies on the role of prostaglandins in the control of aldosterone secretion, analysis of the role of angiotensin II, potassium and ACTH in the induction of hyperaldosteronism in the sodium-depleted rat
1981-1985: demonstration of the role of calmodulin in glomerulosa cells, description of calcium compartments in glomerulosa cells, analysis of the effects of angiotensin II on phosphoinositide and calcium metabolism in glomerulosa cells, demonstration of the aldosterone stimulatory action of vasopressin
1985-1987: development of the technique of high specific activity labelling of inositol 1,4,5-trisphosphate (IP3), description and characterization of IP3 receptors in permeabilized cells and subcellular fractions from several tissues (hepatocytes, polymorphonuclears and liver, pituitary, adrenal cortex, resp.), description of the interaction of IP3 and IP4 in pituitary microsomes
1987-1989: demonstration of Na+/H+ and Na+/Ca2+ antiporters in glomerulosa cells, studies on Ca2+ influx mechanisms in glomerulosa cells
1990-1992: analysis of the mechanism of depolarization and its role in the induction of Ca2+ influx in angiotensin-stimulated glomerulosa cells; demonstration of the activation of mitochondrial metabolism by cytoplasmic Ca2+ signal in intact
1990-1993: intracellular localization of IP3 receptor, characterization of various subtypes of IP3 receptor in glomerulosa cells
1992-1994: demonstration of Ca2+ – induced formation of NAD(P)H in intact cells
1993-1995: characterization of Ca2+ channel subtypes in glomerulosa cells
1993-: studies on mitochondrial Ca2+ uptake and on the effect of Ca2+ signal on mitochondrial metabolism
2013-2015: control of cAMP formation in mitochondria
2015- : effect of mitochondrial cAMP on mitochondrial calcium metabolism

Publications: https://vm.mtmt.hu/search/slist.php?lang=0&AuthorID=10000514

last updated: September 2025