https://www.mdpi.com/journal/molecules/special_issues/separation_analytical
Dear Colleagues,
Chirality is a property of asymmetry that governs all life since all molecules in nature function in the form of pure enantiomers. Many synthetic substances exist and are used in different domains as racemic mixtures; however, in several cases, there are well-documented differences in the effects, pharmacokinetic profiles, toxicity, or environmental fate of individual enantiomers. The development of new advanced analytical methods for the enantioseparation of chiral substances is a necessity, but also remains one of the most challenging tasks in separation science.
The guidelines issued by regulating authorities (FDA, EMA) for the development of new pharmaceuticals call for effective enantiomeric purity control methods. During the last three decades, a wide range of approaches were reported based on chromatographic techniques (high-performance liquid chromatography (HPLC), gas chromatography (GC), supercritical fluid chromatography (SFC)) and electrophoretic techniques (capillary electrophoresis (CE), capillary electrochromatography (CEC)) for enantiomeric separations on an analytical scale.
HPLC can be used to separate enantiomers either directly by using chiral stationary phases or chiral mobile-phase additives or indirectly by employing chiral derivatization reagents. The same methodologies can also be applied for CE separations; however, most of the CE methods used the direct approach by simply dissolving one or more chiral selectors in the background electrolyte.
This Special Issue covers all aspects related to the enantioseparation of chiral substances of pharmaceutical interest, emphasizing the enantiospecific determination of bioactive molecules in complex matrices, including biological matrices. Additionally, research and review articles related to new aspects of chiral synthesis, analysis, pharmacokinetic and pharmacodynamic aspects of drugs are also welcome.
Dr. Gergo Toth
Dr. Gabriel Hancu
Dr. Zoltán István Szabó
Guest Editors
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https://www.mdpi.com/journal/molecules/special_issues/separation_analytical