{"id":52,"date":"2026-03-24T10:30:28","date_gmt":"2026-03-24T09:30:28","guid":{"rendered":"https:\/\/scholar.semmelweis.hu\/kissrichard\/?page_id=52"},"modified":"2026-04-06T17:17:35","modified_gmt":"2026-04-06T15:17:35","slug":"kutatas","status":"publish","type":"page","link":"https:\/\/scholar.semmelweis.hu\/kissrichard\/kutatas\/","title":{"rendered":"Research"},"content":{"rendered":"

\"\"<\/h1>\n

ABOUT THE RESEARCH GROUP<\/h1>\n

The Paediatric Neoplasms Diagnostic Advancements (PANDA) Research Group was established in 2025 at the 1st<\/sup> Department of Pathology and Experimental Cancer Research, Semmelweis University, Budapest, under the leadership of Rich\u00e1rd Kiss, M.D., Ph.D. The group\u2019s core focus is the molecular genetic characterisation and comprehensive genomic profiling of childhood tumours \u2014 with particular emphasis on soft tissue sarcomas and other rare paediatric solid tumours \u2014 and the identification of therapeutically targetable alterations. The research group works in close collaboration with the 2nd<\/sup> Department of Paediatrics, Semmelweis University (Monika Cs\u00f3ka, M.D. PhD. and Mikl\u00f3s Garami, M.D., Ph.D.) and the HCEMM-SU Molecular Oncohematology Research Group (Csaba B\u00f6d\u00f6r, Ph.D.).<\/p>\n

FUNDING<\/h1>\n

The group\u2019s research activities are primarily supported by the following grant:<\/p>\n

PD-OTKA Grant (2022\u20132025)<\/strong>, National Research, Development and Innovation Office (NKFIH)<\/p>\n

\u201cCharacterization of the clonal evolution of childhood soft tissue sarcomas and investigation of their therapeutic targets by molecular genetic methods\u201d<\/em><\/p>\n

Principal Investigator: Rich\u00e1rd Kiss, M.D., Ph.D.\u00a0 |\u00a0 Duration: 2022\u20132025\u00a0 |\u00a0 Funder: NKFIH PD-OTKA<\/p>\n

The project aims to map the somatic mutational landscape, copy number alterations, and clonal evolution of childhood soft tissue sarcomas using multiplex ligation-dependent probe amplification (MLPA), next-generation sequencing (NGS), and other comprehensive genomic approaches, with particular focus on identifying clinically actionable therapeutic targets.<\/p>\n

RESEARCH ACTIVITIES<\/h1>\n

P\u00e9ter Botos \u2013 doctoral student (2025\u2013)<\/strong><\/p>\n

P\u00e9ter Botos commenced his doctoral studies at the Doctoral School of Pathological Sciences in 2025. His primary supervisor is Rich\u00e1rd Kiss, M.D., Ph.D., and his co-supervisor is Prof. Mikl\u00f3s Garami (2nd Department of Paediatrics, Semmelweis University). His doctoral research is embedded within the PANDA Research Group\u2019s programme on childhood tumour diagnostics and molecular genetics, with particular focus on mapping oncologically relevant gene alterations and establishing the foundations for precision therapeutic approaches in paediatric malignancies.<\/p>\n

Kata J\u00falia P\u00e1los, M.D. \u2013 individual PhD student (2025\u2013)<\/strong><\/p>\n

Research topic: <\/strong>Investigation of the genetic background of tumour predisposition syndromes manifesting in childhood by next-generation sequencing<\/em><\/p>\n

Awards (1st author):<\/strong><\/p>\n

Meeting of Young Pathologists \u2013 1st prize<\/p>\n

Kamilla Liszi \u2013 graduate student (2025\u2013)<\/strong><\/p>\n

Research topic: <\/strong>Investigation of the genetic background of tumour predisposition syndromes manifesting in childhood by next-generation sequencing<\/em><\/p>\n

P\u00e9ter Vad\u00f3cz \u2013 graduate student (2025\u2013)<\/strong><\/p>\n

Research topic: <\/strong>Mapping the genetic background of vascular anomalies in childhood<\/em><\/p>\n

Zita Danyi \u2013 graduate student (2024\u2013)<\/strong><\/p>\n

Research topic: <\/strong>Mapping clinically relevant cytogenetic alterations by optical genome mapping in neuroblastoma<\/em><\/p>\n

J\u00falia Marianna K\u00e1rp\u00e1ti \u2013 graduate student<\/strong><\/p>\n

J\u00falia Marianna K\u00e1rp\u00e1ti completed her graduate thesis under the supervision of Rich\u00e1rd Kiss and successfully defended it in 2025. Her research focused on the identification of therapeutically targetable molecular genetic alterations in childhood soft tissue sarcomas by comprehensive genomic profiling \u2014 a topic directly aligned with the core research direction of the PANDA group and the PD-OTKA grant.<\/p>\n

Thesis title: <\/strong>\u201cMapping of Therapeutically Targetable Molecular Genetic Alterations in Paediatric Soft Tissue Sarcomas by Comprehensive Genomic Profiling\u201d<\/em><\/p>\n

Awards (2025, 1st author):<\/strong><\/p>\n

Scientific Students\u2019 Conference (TDK) \u2013 1st place + Special Award of the Hungarian Society of Pediatricians<\/p>\n

National Scientific Students\u2019 Conference (OTDK) \u2013 2nd place + Special Award of the Hungarian Society of Human Genetics and Genomics<\/p>\n

XXIX. Frigyes Kor\u00e1nyi Scientific Forum \u2013 3rd place<\/p>\n

Meeting of Young Pathologists \u2013 1st prize<\/p>\n

Rector\u2019s Competition \u2013 3rd prize<\/p>\n

Janka H\u00e9di H\u00f3fer \u2013 graduate student<\/strong><\/p>\n

Janka H\u00e9di H\u00f3fer also completed her graduate thesis under the supervision of Rich\u00e1rd Kiss and successfully defended it in 2025. Her research focuses on the spatial and temporal investigation of the clonal evolution of childhood soft tissue tumours by molecular genetic methods \u2014 an approach that forms one of the cornerstones of precision oncology and targeted therapy development. H\u00f3fer is also a co-author of the PANDA Research Group\u2019s 2025 publication in Orvosi Hetilap, cited below.<\/p>\n

Thesis title: <\/strong>\u201cInvestigation of the Spatial and Temporal Clonal Evolution of Paediatric Soft Tissue Tumours by Molecular Genetic Methods\u201d<\/em><\/p>\n

Awards:<\/strong><\/p>\n

Rector\u2019s Competition \u2013 Honorable Mention (2025)<\/p>\n

Scientific Students\u2019 Conference (TDK) \u2013 3rd prize (2026)<\/p>\n

PARTNERS<\/h1>\n

HCEMM-SE Molecular Oncohematology Research Group<\/p>\n

Turbine ltd.<\/p>\n

Hungarian Paediatric Oncology Network<\/p>\n

SELECTED PUBLICATIONS<\/h1>\n

The following publication is directly associated with the research activities of the PANDA Research Group:<\/p>\n

H\u00f3fer JH, K\u00e1rp\u00e1ti JM, Bedics G et al., Kiss R<\/strong><\/p>\n

\u201cThe role of molecular pathology in the diagnostics and treatment of childhood tumours\u201d<\/em><\/p>\n

Orvosi Hetilap, 2025; 166(40):1563\u20131573\u00a0 |\u00a0 IF: 0.9\u00a0 |\u00a0 JCI: Q3\u00a0 |\u00a0 MTMT ID: 36366844<\/p>\n

This review article summarises the role of molecular pathological methods \u2014 including next-generation sequencing, fluorescence in situ hybridisation, and immunohistochemistry \u2014 in the diagnostics and treatment of the most common childhood tumours: soft tissue sarcomas, bone tumours, neuroblastoma, nephroblastoma, hepatoblastoma, brain tumours, and haematological malignancies. The first author is Janka H\u00e9di H\u00f3fer, a graduate student of the PANDA Research Group; Rich\u00e1rd Kiss appears among the senior authors.<\/p>\n","protected":false},"excerpt":{"rendered":"

ABOUT THE RESEARCH GROUP The Paediatric Neoplasms Diagnostic Advancements (PANDA) Research Group was established in 2025 at the 1st Department of Pathology and Experimental Cancer Research, Semmelweis University, Budapest, under the leadership of Rich\u00e1rd Kiss, …<\/p>\n","protected":false},"author":125,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-52","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/scholar.semmelweis.hu\/kissrichard\/wp-json\/wp\/v2\/pages\/52"}],"collection":[{"href":"https:\/\/scholar.semmelweis.hu\/kissrichard\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/scholar.semmelweis.hu\/kissrichard\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/scholar.semmelweis.hu\/kissrichard\/wp-json\/wp\/v2\/users\/125"}],"replies":[{"embeddable":true,"href":"https:\/\/scholar.semmelweis.hu\/kissrichard\/wp-json\/wp\/v2\/comments?post=52"}],"version-history":[{"count":9,"href":"https:\/\/scholar.semmelweis.hu\/kissrichard\/wp-json\/wp\/v2\/pages\/52\/revisions"}],"predecessor-version":[{"id":69,"href":"https:\/\/scholar.semmelweis.hu\/kissrichard\/wp-json\/wp\/v2\/pages\/52\/revisions\/69"}],"wp:attachment":[{"href":"https:\/\/scholar.semmelweis.hu\/kissrichard\/wp-json\/wp\/v2\/media?parent=52"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}