{"id":953,"date":"2019-07-25T13:08:47","date_gmt":"2019-07-25T11:08:47","guid":{"rendered":"http:\/\/scholar.semmelweis.hu\/bodorc\/?p=953"},"modified":"2019-07-25T13:08:50","modified_gmt":"2019-07-25T11:08:50","slug":"a-terapia-indukalt-terbeli-heterogenitas-elso-peldajat-kozoltuk-cll-ben","status":"publish","type":"post","link":"https:\/\/scholar.semmelweis.hu\/bodorc\/2019\/07\/25\/a-terapia-indukalt-terbeli-heterogenitas-elso-peldajat-kozoltuk-cll-ben\/","title":{"rendered":"A ter\u00e1pia induk\u00e1lt t\u00e9rbeli heterogenit\u00e1s els\u0151 p\u00e9ld\u00e1j\u00e1t k\u00f6z\u00f6lt\u00fck CLL-ben"},"content":{"rendered":"\n<div class=\"wp-block-image\"><figure class=\"alignleft is-resized\"><img loading=\"lazy\" decoding=\"async\" src=\"http:\/\/scholar.semmelweis.hu\/bodorc\/wp-content\/uploads\/sites\/40\/2019\/07\/image-3.png\" alt=\"\" class=\"wp-image-955\" width=\"151\" height=\"202\" srcset=\"https:\/\/scholar.semmelweis.hu\/bodorc\/wp-content\/uploads\/sites\/40\/2019\/07\/image-3.png 329w, https:\/\/scholar.semmelweis.hu\/bodorc\/wp-content\/uploads\/sites\/40\/2019\/07\/image-3-224x300.png 224w\" sizes=\"(max-width: 151px) 100vw, 151px\" \/><\/figure><\/div>\n\n\n\n<p>A tumorok t\u00e9rbeli \u00e9s id\u0151beli klon\u00e1lis v\u00e1ltozatoss\u00e1ga r\u00e9g\u00f3ta elfogadott, azonban molekul\u00e1ris alapon sok\u00e1ig komoly kih\u00edv\u00e1snak bizonyult ezen jelens\u00e9gek vizsg\u00e1lata.<\/p>\n\n\n\n<p>Kiss Rich\u00e1rd vezet\u00e9s\u00e9vel megjelent \u00faj k\u00f6zlem\u00e9ny\u00fcnk chronicus lymphoid leukaemi\u00e1ban (CLL) a ter\u00e1pia induk\u00e1lt t\u00e9rbeli heterogenit\u00e1s els\u0151 p\u00e9ld\u00e1j\u00e1t mutatja be egy esetle\u00edr\u00e1son kereszt\u00fcl. A 47 \u00e9ves f\u00e9rfi betegn\u00e9l a BTK g\u00e1tl\u00f3 ibrutinib ter\u00e1pia sor\u00e1n r\u00e9szleges v\u00e1laszt k\u00f6vet\u0151en progresszi\u00f3 jelentkezett. Elv\u00e9gezve a csontvel\u0151b\u0151l \u00e9s a Richter-transzform\u00e1ci\u00f3 sz\u00f6vettani k\u00e9p\u00e9t mutat\u00f3 nyirokcsom\u00f3b\u00f3l a ter\u00e1pia rezisztencia h\u00e1tter\u00e9ben \u00e1ll\u00f3 g\u00e9nek vizsg\u00e1lat\u00e1t, a k\u00e9t, azonos id\u0151pontb\u00f3l sz\u00e1rmaz\u00f3 mint\u00e1ban elt\u00e9r\u0151 g\u00e9nek ibrutinib rezisztenci\u00e1t eredm\u00e9nyez\u0151 mut\u00e1ci\u00f3i voltak kimutathat\u00f3k, amelyek a ter\u00e1pia hat\u00e1s\u00e1ra l\u00e9trej\u00f6v\u0151 konvergens evol\u00faci\u00f3 eredm\u00e9ny\u00e9nek tekinthet\u0151k. A mindk\u00e9t kompartment sejtmentes kering\u0151 tumor DNS-\u00e9t tartalmaz\u00f3 liquid-biopszi\u00e1s mint\u00e1b\u00f3l kimutathat\u00f3 volt mindk\u00e9t rezisztencia mut\u00e1ci\u00f3, amely r\u00e1mutat a liquid-biopszia jelent\u0151s\u00e9g\u00e9re a t\u00e9rbeli v\u00e1ltozatoss\u00e1g kimutat\u00e1s\u00e1ban.<\/p>\n\n\n\n<p>A k\u00f6zlem\u00e9ny teljes terjedelm\u00e9ben a kiad\u00f3 <a href=\"http:\/\/www.haematologica.org\/content\/104\/1\/e38.long\">honlapj\u00e1n<\/a> olvashat\u00f3.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>A tumorok t\u00e9rbeli \u00e9s id\u0151beli klon\u00e1lis v\u00e1ltozatoss\u00e1ga r\u00e9g\u00f3ta elfogadott, azonban molekul\u00e1ris alapon sok\u00e1ig komoly kih\u00edv\u00e1snak bizonyult ezen jelens\u00e9gek vizsg\u00e1lata. Kiss Rich\u00e1rd vezet\u00e9s\u00e9vel megjelent \u00faj k\u00f6zlem\u00e9ny\u00fcnk chronicus lymphoid leukaemi\u00e1ban (CLL) a ter\u00e1pia induk\u00e1lt t\u00e9rbeli heterogenit\u00e1s els\u0151 &hellip;<\/p>\n","protected":false},"author":36,"featured_media":954,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"class_list":["post-953","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-hirek"],"_links":{"self":[{"href":"https:\/\/scholar.semmelweis.hu\/bodorc\/wp-json\/wp\/v2\/posts\/953"}],"collection":[{"href":"https:\/\/scholar.semmelweis.hu\/bodorc\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/scholar.semmelweis.hu\/bodorc\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/scholar.semmelweis.hu\/bodorc\/wp-json\/wp\/v2\/users\/36"}],"replies":[{"embeddable":true,"href":"https:\/\/scholar.semmelweis.hu\/bodorc\/wp-json\/wp\/v2\/comments?post=953"}],"version-history":[{"count":1,"href":"https:\/\/scholar.semmelweis.hu\/bodorc\/wp-json\/wp\/v2\/posts\/953\/revisions"}],"predecessor-version":[{"id":956,"href":"https:\/\/scholar.semmelweis.hu\/bodorc\/wp-json\/wp\/v2\/posts\/953\/revisions\/956"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/scholar.semmelweis.hu\/bodorc\/wp-json\/wp\/v2\/media\/954"}],"wp:attachment":[{"href":"https:\/\/scholar.semmelweis.hu\/bodorc\/wp-json\/wp\/v2\/media?parent=953"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/scholar.semmelweis.hu\/bodorc\/wp-json\/wp\/v2\/categories?post=953"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/scholar.semmelweis.hu\/bodorc\/wp-json\/wp\/v2\/tags?post=953"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}